Editor's Comment: "It Ain't Necessarily So"

It Ain’t Necessarily So: Checking Charts for Robustness

Graphics such as statistical charts are crucial tools for communicating the essence of data, but require care in their construction: a chart for a given data set could appear to tell a range of stories, depending just on parameter values used in generating the chart. We are investigating how providing an interactive history of chart-parameter manipulations could encourage people to check the ro...

Low-dose aspirin and stroke. "It ain't necessarily so".

Most clinicians have assumed that very low doses of aspirin might be effective in preventing stroke and death in patients presenting with transient ischemic attacks (TIAs) and stroke. In fact, 325 mg/day or less are often advocated despite the large numbers of well-designed, prospective controlled studies involving stroke-threatened patients that demonstrate the effect of doses greater than 975...

It ain't necessarily so: Basic sequent systems for negative modalities

We look at non-classical negations and their corresponding adjustment connectives from a modal viewpoint, over complete distributive lattices, and apply a very general mechanism in order to offer adequate analytic proof systems to logics that are based on them. Defining non-classical negations within usual modal semantics automatically allows one to treat equivalent formulas as synonymous, and ...

Adjuvant chemotherapy for postmenopausal lymph node-negative breast cancer: it ain't necessarily so.

Adjuvant chemotherapy in older women diagnosed with lowrisk, estrogen receptor (ER)-positive breast cancer still inspires controversy. In fact, there is very little information on polychemotherapy in women aged 70 years or older (1), a direct result of our long-standing failure as cancer investigators to recruit older women to clinical trials. In this issue of the Journal, the International Bre...

It ain't necessarily so: the cost implications of health care reform.